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KMID : 0388120050140010029
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Journal of Korean Society for the Study of Obesity
2005 Volume.14 No. 1 p.29 ~ p.38
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An Activated of Peroxisome Proliferator-Activated Recepter [delta] Attenuate Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease in Rats
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Kim Sun-Mee
Yoon Do-Kyung
Yang Beom-Seok
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Abstract
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Background: Author used the rat model of alcoholic and nonalcoholic liver disease in which feeding dietary with ethanol and high fat result in the development of fatty liver, necrosis, and inflammation. Author used PPAR- agonist in study group. Author investigated that δ pharmacological PPAR- agonist can treat not only the δ pathological manifestations of alcohol or high fat induced liver injury but also alcohol or high fat induced biochemical and histological inflammatory changes in liver.
Methods: Rats were divided into five groups by diet and treatment; a liquid control diet group, a liquid high-fat diet group; a liquid high-fat diet with PPAR-δ agonist L-165041 treatment group; a liquid ethanol diet group; and liquid ethanol diet with PPAR- agonist δ L-165041 treatment group. Here we investigated the role of PPAR- agonist in alcoholic and nonalcoholic liver δ injury, and showed the biochemistry measurements and pathologic finding of treatment of alcoholic fatty liver disease and nonalcoholic fatty liver disease with PPAR-δ agonist L165041.
Results: PPAR- agonist eliminated high-fat and δ ethanol feeding-induced liver steatosis and reduced weight
gain ( P< 0.05). PPAR- agonist treatment induced signif δ - icantly decreases in alanine aminotransferase ( P<0.05),
total cholesterol ( P< 0.05), and insulin ( P< 0.05) and increases in high density lipoprotein cholesterol ( P< 0.05) in
plasma, in nonalcoholic fatty liver disease. Rats with alcoholic and nonalcoholic fatty liver disease challenged with PPAR- agonist treatment had no obvious effects on δ the levels of plasma adiponectin and TNF-α.
Conclusion: This study suggests a protective role for PPAR- in alcoholic and nonalcoholic fatty liver disease, δ
with possible no involvement of adiponectin.
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KEYWORD
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Peroxisome proliferators-activated receptor-Adiponectin, Nonalcoholic fatty liver dis δ -ease, Alcoholic fatty liver disease, TNF-α
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